Table of Contents:
- 1. How Antidepressants Affect Weight Loss
- 2. How Antidepressants Can Lead to Weight Loss
- 3. How Antidepressants May Help With Weight Loss
- 4. How Antidepressants Can Cause Weight Loss
- 5. How Antidepressants Affect Appetite
- 6. How Antidepressants Affect Metabolism
- 7. How Antidepressants Affect Exercise
- 8. How Antidepressants Affect Sleep
Depression is often accompanied by weight gain or weight loss. Antidepressants can affect weight in a variety of ways. To know more read how antidepressants affect weight loss & mental health.
Some people may experience weight loss as a result of their depression, while others may find that their antidepressant medication causes them to gain weight.
If you’re struggling with your weight and depression, you’re not alone. Many people who take antidepressants experience changes in their weight.
In fact, antidepressants are one of the most common medications that can cause weight changes.

1. How Antidepressants Affect Weight Loss
The National Institutes of Health report that 2.4 million American adults suffer from depression, and antidepressants are one of the most commonly prescribed treatments.
According to the National Library of Medicine, common side effects of antidepressants include weight gain. As a result, many people worry about how these medications will affect their weight-loss goals.
There are a variety of different types of antidepressants on the market, and each one can have different effects on weight. For example, selective serotonin reuptake inhibitors (SSRIs) are a type of antidepressant that is often associated with weight gain.
However, not all SSRIs cause weight gain. In fact, some studies have shown that certain SSRIs (such as fluoxetine) may actually help with weight loss.
Another type of antidepressant, called tricyclic antidepressants (TCAs), has also been linked to weight gain. However, like SSRIs, not all TCAs cause weight gain.
Some research has shown that certain TCAs (such as amitriptyline) may actually help with weight loss.
It’s also important to keep in mind that weight gain is not always due to the medication itself. Depression can also lead to changes in appetite and eating habits, which can ultimately lead to weight gain.
That’s why it’s important to work closely with your doctor to manage your depression and your weight-loss goals.

2. How Antidepressants Can Lead to Weight Loss
There are a variety of antidepressants available, and each one comes with its own potential side effects. Some of these side effects can lead to weight loss, while others may cause weight gain.
It’s important to talk to your doctor about any potential side effects before starting antidepressant medication. If you experience any unwanted side effects, be sure to tell your doctor so they can help you manage them.
Some antidepressants that may cause weight loss include:
SSRIs
Selective serotonin reuptake inhibitors are a type of antidepressant that can lead to weight loss in some people. SSRIs work by increasing levels of serotonin in the brain, which can have an appetite-suppressing effect.
SNRIs
Serotonin and norepinephrine reuptake inhibitors are other types of antidepressants that may cause weight loss. Like SSRIs, they work by increasing neurotransmitter levels in the brain, which can have an impact on appetite.
MAO inhibitors
Monoamine oxidase inhibitors are an older type of antidepressant that may also lead to weight loss. These drugs work by blocking the action of monoamine oxidase enzymes, which helps to increase levels of serotonin and other neurotransmitters in the brain.

3. How Antidepressants May Help With Weight Loss
There are many different ways that antidepressants might help with weight loss. Some of these mechanisms are well understood, while others are not.
Let’s take a look at a few potential mechanisms by which antidepressants may help with weight loss:
1. Antidepressants May Boost Metabolism
One potential mechanism by which antidepressants could help with weight loss is by increasing metabolism. A faster metabolism means that your body burns more calories at rest, which could lead to weight loss over time.
Unfortunately, there is limited research on this topic, and the available studies have been inconclusive.
2. Antidepressants May Suppress Appetite
Another potential mechanism by which antidepressants could help with weight loss is by suppressing appetite. Several types of antidepressants are known to have this effect, including tricyclic antidepressants and MAOIs.
If you are taking an antidepressant that suppresses your appetite, you may find it easier to eat fewer calories and lose weight as a result.
3. Antidepressants May Change How Your Body Stores Fat
A third potential mechanism by which antidepressants could help with weight loss is by changing how your body stores fat.
Specifically, some types of antidepressants (such as SSRIs) may increase the amount of fat that your body burns (rather than storing it).
This could lead to weight loss over time, although the research on this topic is limited.
It’s important to note that there is currently no evidence that any specific antidepressant is more likely to cause weight loss than another.
So, if you are interested in using an antidepressant for weight loss, you will need to talk to your doctor about the risks and benefits of different types of medications.
4. How Antidepressants Can Cause Weight Loss
For some people, taking an antidepressant can lead to weight loss. This is most common with older antidepressants, such as tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs).
These medications work by affecting different chemicals in the brain, which can lead to a decrease in appetite.
Other antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), don’t seem to have the same effect on weight. In fact, people taking SSRIs may actually gain weight.
This is most likely due to the fact that SSRIs increase levels of serotonin in the brain, which can lead to increased appetite and cravings for high-calorie foods.
5. How Antidepressants Affect Appetite
While most people don’t gain weight while taking antidepressants, those who do may be more likely to feel hungrier than they did before starting the medication.
If you’re concerned about weight gain, talk to your doctor about medications that are less likely to cause this side effect.

6. How Antidepressants Affect Metabolism
It’s no secret that many antidepressants have many unwanted side effects. Nausea, drowsiness, and dry mouth are just a few more common ones. But did you know that many of these medications can also cause weight gain?
That’s right. While some antidepressants may cause you to lose a few pounds at first, they can eventually lead to weight gain. And the opposite is also true. Some antidepressants can help you lose weight.
So how do antidepressants affect metabolism? The answer isn’t always straightforward. It seems that each person reacts differently to these medications. And, of course, there are other factors that can influence weight loss or gains, such as diet and exercise.
But there are some general trends worth noting. For example, antidepressants in the SSRI class (selective serotonin reuptake inhibitors) tend to be associated with weight gain.
These include medications like Prozac, Zoloft, and Paxil. On the other hand, tricyclic antidepressants often lead to weight loss. These include medications like Elavil and Tofranil.
Of course, every person is different. So if you’re concerned about how an antidepressant might affect your weight, be sure to talk to your doctor about your concerns.
He or she can help you figure out which medication is best for you—with your weight in mind!
7. How Antidepressants Affect Exercise
Depression not only decreases your motivation to exercise but also makes it harder for you to find pleasure in activities that used to make you happy.
In addition, some types of antidepressants can lead to weight gain, making it even harder to muster the energy or desire to be active.
If you’re struggling with depression and trying to lose weight or maintain a healthy weight, talk with your doctor about which type of medication is right for you.
8. How Antidepressants Affect Sleep
Depression can make it hard to fall asleep and stay asleep. Antidepressants can help improve sleep quality by correcting the underlying chemical imbalance that is causing sleep problems.
There are different types of antidepressants, and each one can have different effects on sleep.
Some people may find that their antidepressant makes them feel more awake and energetic, while others may find that it makes them feel more sleepy.
The type of antidepressant that you take can also affect how well it works for treating depression. Some antidepressants are more likely to cause weight gain than others.
This is something to discuss with your doctor before starting treatment.
Related Post: